Explanation

VM2: West US
In RG2, which is in West US, you need to create a new virtual machine named VM2.
VM2_interface: East US
VM2 will use a network interface named VM2_Interface to connect to VNET1, which is in East US.
References:
https://docs.microsoft.com/en-us/azure/virtual-network/associate-public-ip-address-vm