To protect an Azure SQL Managed Instance from Azure region failures, you should enable zone redundancy for high availability within the region and implement disaster recovery with failover groups to a secondary region. Zone redundancy ensures resilience to zonal outages, while failover groups enable failover to a secondary instance in case of a region-wide outage. 1. Zone Redundancy: Enable zone redundancy to ensure the managed instance is distributed across multiple availability zones within the same region. This provides redundancy against hardware and software failures in a single zone, maintaining high availability with up to 99.99% SLA. You can enable zone redundancy through the Azure portal or PowerShell. 2. Disaster Recovery with Failover Groups: Create a failover group that includes your primary managed instance and a secondary managed instance in a different region. The secondary instance serves as a failover target in case of a region-wide outage. Configure the failover group to replicate data continuously between the instances, ensuring minimal data loss during a failover. Reference: https://learn.microsoft.com/en-us/azure/azure-sql/managed-instance/disaster-recovery-guidance