Explanation:
Box 1: Integrated Security=SSPI
Integrated security: For all data source types, connect using the current user account.
For SqlClient you can use Integrated Security=true; or Integrated Security=SSPI; Scenario: All access to Azure Storage and Azure SQL database must use the application's Managed Service Identity (MSI) Box 2: Encrypt = True Scenario: All data must be protected in transit.
References:
https://docs.microsoft.com/en-us/dotnet/framework/data/adonet/connection-string-syntax