Microservices architecture is the most suitable design principle that aligns with the security best practices mentioned. It involves developing a suite of small services, each running in its own process and communicating with lightweight mechanisms, often an HTTP resource API. This architecture minimizes the services running on each layer, allows for vendor-agnostic solutions, and is well-suited for virtualization over physical hardware.
Reference: Microservices as an architectural approach is discussed in the context of cloud-native applications within the CompTIA Cloud+ material.