Cisco ISE is a platform that can onboard the endpoint and can issue a CA signed certificate while also automatically configuring endpoint network settings to use the signed endpoint certificate, allowing the endpoint to gain network access. Cisco ISE has an internal CA service that can validate and sign certificate requests from endpoints, generate and store keys and certificates, and provide an OCSP responder to check the validity of certificates. Cisco ISE also supports Enrollment over Secure Transport (EST), which is a protocol that allows endpoints to securely enroll with a CA and obtain certificates. Cisco ISE can use EST to provision certificates to endpoints and configure their network settings to use EAP-TLS authentication. Cisco ISE can also use BYOD workflows to onboard endpoints and issue certificates to them. References:
* Understand ISE Internal Certificate Authority Services
* Endpoint On-boarding using Internal ISE CA
* Cisco ISE BYOD Prescriptive Deployment Guide