Explanation:

Box 1: An Azure SQL Database single database.
SQL Server Managed instance versus SQL Server Virtual Machines
Active geo-replication is not supported by Azure SQL Managed Instance.
Box 2: Active geo-replication
Active geo-replication is a feature that lets you to create a continuously synchronized readable secondary database for a primary database. The readable secondary database may be in the same Azure region as the primary, or, more commonly, in a different region. This kind of readable secondary databases are also known as geo-secondaries, or geo-replicas.
Reference:
https://docs.microsoft.com/en-us/azure/azure-sql/database/active-geo-replication-overview