Explanation
Box 1: Yes
Box 2: Yes
AAP application server to database server latency can be tested with ABAPMeter report /SSA/CAT.
Box 3: Yes
To analyze network issue or measure network metrics you can test the connection using SAP's NIPING program. You can use NIPING to analyze the network connection between any two machines running SAP software.
Reference:
https://azure.microsoft.com/sv-se/blog/azure-availability-zones-expand-with-new-services-and-to-new-regions-in
https://azure.microsoft.com/en-us/blog/sap-on-azure-architecture-designing-for-performance-and-scalability/
https://wiki.scn.sap.com/wiki/pages/viewpage.action?pageId=360974069
https://docs.microsoft.com/en-us/azure/virtual-machines/workloads/sap/sap-ha-availability-zones#:~:text=In%20