Explanation
E: The network latency across Availability Zones is not the same in all Azure regions. In some cases, you can deploy and run the SAP application layer across different zones because the network latency from one zone to the active DBMS VM is acceptable. But in some Azure regions, the latency between the active DBMS VM and the SAP application instance, when deployed in different zones, might not be acceptable for SAP business processes.
References:
https://docs.microsoft.com/en-us/azure/virtual-machines/workloads/sap/sap-ha-availability-zones