SFTP (Secure File Transfer Protocol) operates over port 22, using SSH (Secure Shell) encryption for secure file transfers. Breakdown of Options: A: 22 - Correct answer. SFTP runs over SSH (port 22) for secure file transfers. B: 80 - Used for HTTP, not SFTP. C: 443 - Used for HTTPS (secure web traffic). D: 3389 - Used for RDP (Remote Desktop Protocol). Reference: CompTIA Network+ (N10-009) Official Study Guide - Domain 3.1: Compare and contrast network protocols. RFC 4253: SSH Transport Layer Protocol