The system that should be prioritized for patching first is 54.74.110.228, as it has the highest number and severity of vulnerabilities among the four systems listed in the vulnerability report. According to the report, this system has 12 vulnerabilities, with 8 critical, 3 high, and 1 medium severity ratings. The critical vulnerabilities include CVE-2019-0708 (BlueKeep), CVE-2019-1182 (DejaBlue), CVE-2017-0144 (EternalBlue), and CVE-2017-0145 (EternalRomance), which are all remote code execution vulnerabilities that can allow an attacker to compromise the system without any user interaction or authentication. These vulnerabilities pose a high risk to the system and should be patched as soon as possible.