Reference:
https://www.cisco.com/c/en/us/td/docs/security/firepower/60/configuration/guide/fpmc-config-guidev60/Referen Spero analysis only uploads the signature of the (executable) files to the AMP cloud. It does not upload thewhole file. Dynamic analysis sends files to AMP ThreatGrid.Dynamic Analysis submits (the whole) files to Cisco Threat Grid (formerly AMP Threat Grid). Cisco ThreatGrid runs the file in a sandbox environment, analyzes the file's behavior to determine whether the file ismalicious, and returns a threat score that indicates the likelihood that a file contains malware. From the threatscore, you can view a dynamic analysis summary report with the reasons for the assigned threat score. Youcan also look in Cisco Threat Grid to view detailed reports for files that your organization submitted, as well asscrubbed reports with limited data for files that your organization did not submit.Local malware analysis allows a managed device to locally inspect executables, PDFs, office documents, andother types of files for the most common types of malware, using a detection rule set provided by the CiscoTalos Security Intelligence and Research Group (Talos). Because local analysis does not query the AMP cloud,and does not run the file, local malware analysis saves time and system resources. -> Malware analysis doesnot upload files to anywhere, it only checks the files locally.There is no sandbox analysis feature, it is just a method of dynamic analysis that runs suspicious files in avirtual machine.